Figure 2.

p75 structure and regulated intramembrane proteolysis (RIP). p75 consists of four extracellular cysteine-rich domains (CRD1–4), an α-helical TM domain, and an intracellular segment (ICD, p75^ICD) which includes a death domain and the juxtamembrane Chopper domain. The receptor undergoes RIP; α-secretase/ADAM10/17–mediated cleavage in the extracellular domain (ECD) releases an ECD fragment, this is followed by γ-secretase cleavage in the transmembrane domain to yield a soluble p75^ICD fragment. p75 receptor is shown in orange. p75, p75 neurotrophin receptor.