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. 2022 Jan 17;298(3):101568. doi: 10.1016/j.jbc.2022.101568

Figure 3.

Figure 3

Key TrkA kinase domain sites.A, TrkA kinase domain (PDB 4GT5) crystal structure with regions of importance for kinase activation indicated. Inset shows T-stacking interaction between the gatekeeper residue F592 and F672 of the DFG motif. B, schematic representation of the N-lobe and C-lobe shifts, repositioning of the α-C helix, DFG motif, and activation loop, as well as engagement of ATP and phosphorylation of activation loop tyrosine residues between the active and inactive TrkA kinase domains. Trk, tropomyosin receptor kinase.