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. 2022 Feb 11;25(3):103919. doi: 10.1016/j.isci.2022.103919

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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sod-1(G85R) mutant elicits pathogen avoidance response similar to sod-1(tm776) deletion

(A) Sequences of ALS-related mutations sod-1(G85R) and sod-1(G93A) in C. elegans. sod-1(G85R) and sod-1(G93A) are generated via the CRISPR/CAS9 technique. The corresponding DNA sequence is based on the cDNA isoform b of sod-1.

(B) Pathogen avoidance phenotypes of sod-1(G85R) and sod-1(G93A). Error bar represents SEM ∗∗∗ represents p < 0.001. ∗∗∗∗ represents p < 0.0001. ns represents not significant. As determined by one-way ANOVA, followed by Tukey's multiple comparison analysis. N = 12.