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. 2022 Feb 11;25(3):103919. doi: 10.1016/j.isci.2022.103919

Figure 4.

Figure 4

SOD-1 plays a role in regulating synaptic GLR-1 at the ventral nerve cord

(A) Fluorescence micrographs of glr-1p:glr-1:GFP in wild-type N2, sod-1(tm776), sod-1(G85R) and sod-1(G93A) backgrounds. Arrow indicates GLR-1:GFP puncta. Scale bar indicates 10 μm.

(B) sod-1(tm776) and sod-1(G85R) mutant animals have reduced GLR-1:GFP density as compared to wild type.

(C) sod-1(G93A) mutant animals have reduced GLR-1:GFP area as compared to wild type.

(D) sod-1(G85R) and sod-1(G93A) mutant animals have reduced GLR-1:GFP fluorescence intensity as compared to wild type. (B–D) Error bar represents SEM ∗∗∗ represents p < 0.001. ∗∗∗∗ represents p < 0.0001. ns represents not significant. As determined by one-way ANOVA, followed by Tukey's multiple comparison analysis. N = 24.

(E) sod-1(tm776), sod-1(G85R) and sod-1(G93A) mutants elicit reduced spontaneous reversal phenotypes. Error bar represents SEM ∗ represents p < 0.05, ∗∗ represents p < 0.01, as determined by Student’s t test. N = 12.