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. 2022 Feb 16;12:806386. doi: 10.3389/fgene.2021.806386

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Copyright © 2022 Loeffler, Gaisa, Muti, van Treeck, Echle, Ghaffari Laleh, Trautwein, Heij, Grabsch, Ortiz Bruechle and Kather.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the performance of the single gene area under the receiver operating curve (AUROC) vs. pathway AUROC. The top three pathways (A) MAPK, (B) PI3K, (C) TP53 AUROC results for the three top tumor cohorts (STAD, CRC, UCEC) are illustrated. AUROC values are compared between single gene vs. whole pathway. Coloured values stand for significantly detected pathways and grey for not significantly detected (p > 0.05).