TABLE 1.

Top genes result overview. Single gene analysis results with area under the receiver operating curve (AUROC), confidence interval and p-Value. Selected genes were very well predicted by the neural network with AUROCs at least above 0.75. (1–3) FGFR3, PBRM1, IDH1 are clinically relevant, (4–6) CDH1, BRAF is associated with different morphological features and (7–9) SETD2, NOTCH2 have prognostic value.

ID	Tumor type	Gene	AUROC	p-Value
1	BLCA	FGFR3	0.78 [0.72–0.822]	<0.001
2	LGG	IDH1	0.764 [0.735–0.805]	<0.001
3	HNSC	BRAF	0.79 [0.739–0.977]	=0.001
4	THCA	BRAF	0.86 [0.816–0.886]	<0.001
5	BRCA	CDH1	0.81 [0.758–0.849]	<0.001
6	PRAD	SETD2	0.895 [0.827–0.951]	=0.005
7	KIRP	PBRM1	0.752 [0.571–0.939]	=0.006
8	CRC	NOTCH2	0.934 [0.893–0.978]	<0.001
9	STAD	NOTCH2	0.919 [0.846–0.982]	<0.001