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. 2022 Feb 11;25(3):103904. doi: 10.1016/j.isci.2022.103904

Figure 1.

Figure 1

Metaboloepigenetic pathways are species and stage specific

General analysis of human (in vitro), mouse (in vivo) and bovine (in vivo) mature oocyte (MII) and embryos (2, 4, 8, 16C, MO and BL), showing proportion of up (PropUp, red) and down (PropDown, green) regulated metabolic and epigenetic pathways (part of Reactome terms “Metabolism” and “Epigenetic regulation of gene expression”) in 2C compared to MII, 4C compared to 2C, 8C compared to 4C, 16C compared to 8C and BL compared to 16C. Differences were calculated using ROAST, and significance determined using a one-sided directional p value < 0.05.