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. 2022 Feb 11;25(3):103904. doi: 10.1016/j.isci.2022.103904

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Metaboloepigenetic control of DNA and histone methylation

Analysis of human (purple), mouse (green) and bovine (yellow) in vivo (full lines) and in vitro (dashed lines) pre-implantation stages (MII, 2, 4, 8, 16C/MO and BL). The connection between DNA and histone methylation pathways with the one carbon cycle are depicted alongside selected expression pattern among the different pre-implantation stages for each species of selected genes (mean ± SD). For significant up and down regulated genes between stages and species see Figure S2.