Figure 4.

DNA and histone demethylation are controlled by metabolism

Connection between metabolism and DNA and histone demethylation of human (purple), mouse (green) and bovine (yellow) in vivo (full lines) and in vitro (dashed lines) pre-implantation stages (MII, 2, 4, 8, 16C/MO and BL). Pathways related to glucose, pyruvate, α-ketoglutarate and glutamine, metabolism and the TCA cycle, that can directly influence DNA and histone demethylation are depicted alongside each gene expression (mean ± SD pattern among the different pre-implantation stages for each species. For significant up and down regulated genes between stages intra-species see Figure S3.