Figure 7.

Metaboloepigenetic pathways are modified in vitro

General analysis of in vitro bovine and mouse mature oocyte (MII) and embryos (2, 4, 8, 16C, MO and BL), showing proportion of up (PropUp, red) and down (PropDown, green) regulated metabolic and epigenetic pathways (part of Reactome terms “Metabolism” and “Epigenetic regulation of gene expression”) in 2C compared to MII (bovine only), 4C compared to 2C, 8C compared to 4C, 16C compared to 8C and BL compared to 16C. Differences on PropUp and PropDown were calculated using ROAST, and significance determined using a the one-sided directional p value < 0.05