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. 2022 Mar 2;12(3):210320. doi: 10.1098/rsob.210320

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — HCV antigen-specific lysis of A0201 B cell targets by KLVALGINAV CD8⁺ T cell clone SR01-78 from an individual with spontaneous resolved HCV. (a) Schematic detailing exogenous peptide pulsing of liver cells and stimulation of T cells. (b) Sorting strategy for HCV tetramer positive CD8⁺ T cells. (c) Chromium release assay demonstrating antigen-specific lysis of A0201 class I MHC transfected B cell (721.221) exogenously loaded peptide targets (KLVALGINAV and control peptide) and endogenously synthesized antigen targets (vvNS3 and control vvWT) at effector to target ratios of 20 : 1, 5 : 1 and 1 : 1.