Table 1.
Patients’ and BM characteristics
| Total (n=41) |
|
| Characteristics of patients | |
| Age | |
| <65 | 61 |
| ≥65 | 39 |
| Sex (%) | |
| Male | 53.7 |
| Female | 46.3 |
| Primary tumor | |
| Colon | 22 |
| Rectum | 19.5 |
| Stomach | 39 |
| Esophagus | 4.9 |
| Pancreas | 9.8 |
| Bile duct | 2.4 |
| Rectosigmoid | 2.4 |
| Histology | |
| Adenocarcinoma | 90.2 |
| Squamous | 4.9 |
| Neuroendocrine | 4.9 |
| KPS* | 60–90 |
| KPS | |
| ≤70 | 26.8 |
| >70 | 73.2 |
| ds-GPA score | |
| ds-GPA = 1 | 24.4 |
| ds-GPA = 2 | 43.9 |
| ds-GPA = 3 | 31.7 |
| ds-GPA = 4 | 0 |
| GI-GPA score | |
| GI-GPA = 0 | 24.4 |
| GI-GPA = 1 | 39 |
| GI-GPA = 2 | 29.3 |
| GI-GPA = 3 | 7.3 |
| RPA score | |
| 2 | 73.2 |
| 3 | 26.8 |
| Systemic disease status at diagnosis of BM | |
| Controlled | 24.4 |
| Uncontrolled | 75.6 |
| Extracranial metastasis | |
| Lung | 48.8 |
| Bone | 26.8 |
| Liver | 46.3 |
| Systemic lymph node | 29.3 |
| Skin | 2.4 |
| Adrenal gland | 7.3 |
| Interval from diagnosi to extracranial metastasis* | 0–49 |
| Characteristics of BM | |
| Interval from diagnosis to BM* (months) | 0–60 |
| Number of metastasis | |
| 1 | 39 |
| 2 | 19.5 |
| ≥3 | 41.5 |
| Location of BM | |
| Supratentorial | 48.8 |
| Infratentorial | 29.3 |
| Both | 22 |
| Volume of BM (cc)* | 0.34–112 |
| Volume of BM (cc) | |
| <10 cc | 51.2 |
| ≥10 cc | 48.8 |
| Edema | 75.6 |
| Hemorrhage | 39 |
| Neurological symptoms | |
| Headache | 48.7 |
| Ataxia | 7.3 |
| Motor weakness | 29.3 |
| Nausea | 53.6 |
| Mental change | 14.6 |
| Seizure | 7.3 |
| Asymptomatic | 2.4 |
*: Median (minimum–maximum); BM: Brain metastasis; ds-GPA: Diagnosis-specific graded prognostic assessment; GI-GPA: Gastrointestinal graded prognostic assessment; KPS: Karnofsky performance status.