Table 3.
Comparison of WBRT and SBRT
| WBRT (n=24) | SRS (n=17) | p | ||
| WBRT | SRS | p | (n=24) | (n=17) |
| Characteristics of patients | ||||
| Age | ||||
| <65 | 66.7 | 52.9 | 0.375 | |
| ≥65 | 33.3 | 47.1 | ||
| Sex | ||||
| Male | 33.3 | 82.4 | 0.002 | |
| Female | 66.7 | 17.6 | ||
| Primary tumor | ||||
| Colon | 8.3 | 41.2 | 0.027 | |
| Rectum | 16.7 | 23.5 | ||
| Stomach | 50 | 23.5 | ||
| Esophagus | 4.2 | 5.9 | ||
| Pancreas | 16.7 | 0 | ||
| Bile duct | 0 | 5.9 | ||
| Rectosigmoid | 4.2 | 0 | ||
| Histology | ||||
| Adenocarcinoma | 87.5 | 94.1 | ||
| Squamous | 4.2 | 5.9 | ||
| Neuroendocrine | 8.3 | 0 | ||
| KPS* | 0.003 | |||
| KPS | ||||
| ≤70 | 41.7 | 5.9 | 0.014 | |
| >70 | 58.3 | 94.1 | ||
| ds-GPA score | 0.038 | |||
| ds-GPA=1 | 37.5 | 5.9 | ||
| ds-GPA=2 | 41.7 | 47.1 | ||
| ds-GPA=3 | 20.8 | 47.1 | ||
| ds-GPA=4 | 0 | 0 | ||
| GI-GPA score | 0.035 | |||
| GI-GPA=0 | 37.5 | 5.9 | ||
| GI-GPA=1 | 41.7 | 35.3 | ||
| GI-GPA=2 | 16.7 | 47.1 | ||
| GI-GPA=3 | 4.2 | 11.8 | ||
| Systemic disease status at diagnosis of BM | ||||
| Controlled | 20.8 | 29.4 | 0.714 | |
| Uncontrolled | 79.2 | 70.6 | ||
| Extracranial metastasis | ||||
| Lung | 37.5 | 68.7 | 0.053 | |
| Bone | 25 | 35.7 | 0.712 | |
| Liver | 54.2 | 46.2 | 0.642 | |
| Systemic lymph node | 41.7 | 15.4 | 0.103 | |
| Skin | 0 | 7.7 | 0.351 | |
| Adrenal gland | 12.5 | 0 | 0.538 | |
| Interval from diagnosis to extracranial metastasis* | 0 (r: 0–36) |
10 (r: 0–49) |
0.017 | |
| Median OS (months) | 4 | 9 | 0.005 | |
| Characteristics of BM | ||||
| Interval from diagnosis to BM* (months) | 9 (0–40) | 20 (0–60) | 0.008 | |
| Number of metastasis | ||||
| 1 | 25 | 58.8 | 0.102 | |
| 2 | 25 | 11.8 | ||
| ≥3 | 50 | 29.4 | ||
| Location of BM | ||||
| Supratentorial | 45.8 | 52.9 | 0.497 | |
| Infratentorial | 25 | 35.3 | ||
| Both | 29.2 | 11.8 | ||
| Volume of BM (cc)* | 45.9 (r: 0.34–112) |
6.4 (r: 0.46–19.9) |
0.024 | |
| Volume of BM (cc) | ||||
| <10 cc | 37.5 | 70.6 | 0.037 | |
| ≥10 cc | 62.5 | 29.4 | ||
| Edema | 75 | 76.5 | 1 | |
| Hemorrhage | 37.5 | 41.2 | 0.812 |
*: Median (minimum–maximum); BM: Brain metastasis; ds-GPA: Diagnosis-specific graded prognostic assessment; GI-GPA: Gastrointestinal graded prognostic assessment; KPS: Karnofsky performance status; OS: Overall survival; SRS: Stereotactic radiosurgery; WBRT: Whole-brain radiotherapy; r: Range.