Table 3:
Pharmacokinetic parameters of CoQ10 in combination with MAG-OM3, rice oil or alone.
| CoQ10 + MAG-OM3 | CoQ10 + Rice oil | CoQ10 alone | |||||
|---|---|---|---|---|---|---|---|
| Pharmacokinetic parameters | Mean | SEM | Mean | SEM | Mean | SEM | P-value |
| Tmax (h) | 9·5 | 1·3 | 9·6 | 1·3 | 6·9 | 1·1 | 0·6128 |
| C0h (μg/L) | 611·6 | 42·0 | 617·9 | 43·4 | 581·8 | 40·2 | 0·0877 |
| ΔCmax (μg/L) | 281·1 A | 44·5 | 325·1 A | 50·1 | 127·8 B | 26·5 | 0·0015 |
| ΔC48h (μg/L) | 38·3 A | 20·5 | 96·1 B | 26·3 | −17·7 A | 19·2 | 0·0004 |
| AUC 0-6h (μg/L*h) | 576·7 A | 100·0 | 456·1 A | 73·1 | 161·7 B | 41·6 | <0·0001 |
| AUC 0-48h (μg/L*h) | 6211·0 A | 1097·0 | 7216·0 A | 1148·0 | 2199·0 B | 702·6 | <0·0001 |
Results are expressed as mean ± SEM. Tmax = time at which the maximum concentration is reached, C0h = plasma concentration at baseline, ΔCmax = maximum concentration, C48h = plasma concentration 48h post single dose intake, AUC 0-6 h = area under the curve over 6h, AUC 0-48h = area under the curve over 48h. P values were assessed by Friedman nonparametric statistical analysis, with Dunn's multiple comparison test. Data with different letters A and B are statistically different.