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. 2022 Jan 18;11:e2. doi: 10.1017/jns.2021.106

Table 4:

Pharmacokinetic parameters of CoQ10 in combination with MAG-OM3, rice oil or alone in men and women

Pharmacokinetic parameters CoQ10 + MAG-OM3 CoQ10 + Rice oil CoQ10 Alone
Men Women Men Women Men Women P-value
Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM P interaction P sex P supplement
Tmax (h) 7·2 1·5 11·7 2·1 8·7 1·7 10·6 1·9 7·7 1·9 6·1 1·0 0·1772 0·3127 0·1795
C0h (μg/L) 589·6 54·6 633·6 65·3 658·7 58·4 577·1 64·4 614·8 64·5 548·9 48·9 0·0198 0·6691 0·2706
ΔCmax (μg/L) 279·8 67·6 282·4 60·2 373·1 52·1 373·2 85·8 87·0 18·4 168·7 48·3 0·5550 0·3588 0·0003
ΔC48h* (μg/L) 26·5 18·8 51·0 37·9 25·6 18·9 171·5 42·6 -45·5 22·2 8·3 30·0 0·0696 0·0143 0·0002
AUC 0-6h (μg/L*h) 731·3 177·2 422·0 81·3 452·2 113·5 460·1 96·3 99·9 35·3 223·4 73·4 0·0250 0·6176 <0·0001
AUC 0-48h (μg/L*h) 5957·2 1414·1 6464·9 1725·0 4927·9 824·8 9503·1 2007·1 1348·6 489·7 3049·5 1304·5 0·1707 0·1453 <0·0001

Tmax = time at which the maximum concentration is reached, C0h = plasma concentration at baseline, ΔCmax = maximum concentration, ΔC48h = plasma concentration 48h post single dose intake, AUC 0-6 h = area under the curve over 6h, AUC 0-48h = area under the curve over 48h. P values were assessed by a 2-way ANOVA statistical analysis, with Bonferroni's multiple comparison test. The P interaction represents the combined effect of sex and type of supplement while P sex and P supplement represent the individual effect of sex or supplement.

*For the ΔC48h, these data were analyzed by fitting a mixed model, rather than by repeated measures ANOVA because there were missing values, i.e. 3 participants refused to come back on one of their 48h follow-up visit (n = 3).