Table 4:
Pharmacokinetic parameters of CoQ10 in combination with MAG-OM3, rice oil or alone in men and women
| Pharmacokinetic parameters | CoQ10 + MAG-OM3 | CoQ10 + Rice oil | CoQ10 Alone | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | Men | Women | P-value | |||||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | P interaction | P sex | P supplement | |
| Tmax (h) | 7·2 | 1·5 | 11·7 | 2·1 | 8·7 | 1·7 | 10·6 | 1·9 | 7·7 | 1·9 | 6·1 | 1·0 | 0·1772 | 0·3127 | 0·1795 |
| C0h (μg/L) | 589·6 | 54·6 | 633·6 | 65·3 | 658·7 | 58·4 | 577·1 | 64·4 | 614·8 | 64·5 | 548·9 | 48·9 | 0·0198 | 0·6691 | 0·2706 |
| ΔCmax (μg/L) | 279·8 | 67·6 | 282·4 | 60·2 | 373·1 | 52·1 | 373·2 | 85·8 | 87·0 | 18·4 | 168·7 | 48·3 | 0·5550 | 0·3588 | 0·0003 |
| ΔC48h* (μg/L) | 26·5 | 18·8 | 51·0 | 37·9 | 25·6 | 18·9 | 171·5 | 42·6 | -45·5 | 22·2 | 8·3 | 30·0 | 0·0696 | 0·0143 | 0·0002 |
| AUC 0-6h (μg/L*h) | 731·3 | 177·2 | 422·0 | 81·3 | 452·2 | 113·5 | 460·1 | 96·3 | 99·9 | 35·3 | 223·4 | 73·4 | 0·0250 | 0·6176 | <0·0001 |
| AUC 0-48h (μg/L*h) | 5957·2 | 1414·1 | 6464·9 | 1725·0 | 4927·9 | 824·8 | 9503·1 | 2007·1 | 1348·6 | 489·7 | 3049·5 | 1304·5 | 0·1707 | 0·1453 | <0·0001 |
Tmax = time at which the maximum concentration is reached, C0h = plasma concentration at baseline, ΔCmax = maximum concentration, ΔC48h = plasma concentration 48h post single dose intake, AUC 0-6 h = area under the curve over 6h, AUC 0-48h = area under the curve over 48h. P values were assessed by a 2-way ANOVA statistical analysis, with Bonferroni's multiple comparison test. The P interaction represents the combined effect of sex and type of supplement while P sex and P supplement represent the individual effect of sex or supplement.
*For the ΔC48h, these data were analyzed by fitting a mixed model, rather than by repeated measures ANOVA because there were missing values, i.e. 3 participants refused to come back on one of their 48h follow-up visit (n = 3).