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. 2022 Jan 30;298(3):101666. doi: 10.1016/j.jbc.2022.101666

Figure 5.

Figure 5

Docking model of GnT-V and glycoprotein substrates. Structural models of GnT-V complexed with N-glycosylated α1AGP (PDB, 3KQ0) (A), transferrin (PDB, 3V8X) (B), SOD3 (PDB, 2JLP) (C), CCL1 (PDB, 4OIK) (D), and SGP (E). The N domain is connected to the catalytic region via two flexible loops (green dotted circles). N-Glycans on these glycoproteins (or peptide) have the biantennary GlcNAc-terminated structure (GnGnbi) shown in sphere models. α1AGP, alpha-1-acid glycoprotein; GnT-V, N-acetylglucosaminyltransferase-V; SGP, chicken egg sialylglycopeptide; SOD3, superoxide dismutase 3.