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. 2022 Jan 29;298(3):101614. doi: 10.1016/j.jbc.2022.101614

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

mtm-10 gene expression rescues the pathogen-induced dendrite degeneration phenotype of mtm-10 mutants.A, representative photomicrographs of dendrite degeneration after exposure to Pseudomonas aeruginosa for 24 h in mtm-10(ac270) animals and animals expressing mtm-10 under its own promoter mtm-10(ac270); Pmtm-10::mtm-10. In both cases, animals also express RFP in AWC neurons. The scale bars represent 10 μm and 2 μm, respectively. Different morphological changes in the dendrites are indicated with white arrows. B, quantification of the dendrite degeneration phenotype in control CX5974 (parent strain), mtm-10(ac270), and mtm-10(ac270);Pmtm-10::mtm-10 animals expressing RFP in AWC neurons. The black symbols represent individual data points. N = 6, number of animals = 50. Control versus mtm-10(ac270) (p < 0.0001) and mtm-10(ac270) versus mtm-10(ac270);Pmtm-10::mtm-10 (p < 0.0001) via one-way ANOVA test. C, representative photomicrographs of animals expressing RFP under the control of the odr-1 promoter and GFP under the control of the mtm-10 promoter. The scale bars represent 5 μm. ∗∗∗∗p < 0.0001. RFP, red fluorescent protein.