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. 2022 Feb 1;298(3):101665. doi: 10.1016/j.jbc.2022.101665

Figure 1.

Figure 1

A, chemical scaffold of the main classes of β-lactam antibiotics hydrolyzed by MBLs. The β-lactam ring is highlighted in red. B, representative active site for subclasses B1, B2, and B3 MBLs. The Zn(II) ions are represented by black spheres, and water molecules are represented by red spheres. In each panel, metal ligand are highlighted in sticks and the gray dashed lines show coordination geometry spheres for the Zn1 and Zn2 sites. The Protein Data Bank files used are: 3SPU (B1—NDM-1), 3SD9 (B2—SfhI), and 3LVZ (B3–BJP-1). BJP-1, MBL from Bradyrhizobium japonicum; MBL, metallo-β-lactamase; NDM-1, New Delhi metallo-β-lactamase 1; SfhI, MBL from Serratia fonticola.