Table 1.
Differential distribution of plasmid-associated MBLs among bacterial hosts
| MBL host range | Acquired MBL | Ambler subclass | Bacterial hostsa |
|---|---|---|---|
| MBLs found in a narrow range of bacteria | VIM-2 | B1 | Pseudomonas spp. (P. aeruginosa, P. putida, P. stutzeri, P. juntendi, P. asiatica), Serratia marcescens, Acinetobacter baumanii |
| SPM-1 | B1 | Pseudomonas aeruginosa | |
| AIM-1 | B3 | Pseudomonas aeruginosa | |
| SMB-1 | B3 | Serratia marcescens | |
| DIM-1 | B1 | Pseudomonas aeruginosa, Pseudomonas stutzeri | |
| FIM-1 | B1 | Pseudomonas aeruginosa | |
| KHM-1 | B1 | Citrobacter freundii, Enterobacter hormaechei subsp. hoffmannii | |
| SIM-1 | B1 | Acinetobacter spp. (A. baumannii, A. bereziniae and A. baylyi) | |
| MBLs found in a broad range of bacteria | VIM-1 | B1 | Enterobacterales (Enterobacter hormaechei, Klebsiella pneumoniae, Klebsiella michiganensis, Escherichia coli, Kluyvera cryocrescens, Enterobacter cloacae, Salmonella enterica), Pseudomonas aeruginosa |
| IMP-1 | B1 | Pseudomonas aeruginosa, Enterobacterales (Serratia marcescens, Enterobacter cloacae, Enterobacter roggenkampii, Klebsiella pneumoniae, Escherichia coli), Acinetobacter baumannii | |
| NDM-1 | B1 | Enterobacterales (Klebsiella pneumoniae, Salmonella enterica, Escherichia coli, Enterobacter hormaechei, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Citrobacter freundii, Providencia rettgeri), Acinetobacter spp., Pseudomonas aeruginosa, Vibrio cholera | |
| GIM-1 | B1 | Pseudomonas spp. and Enterobacterales (Enterobacter cloacae, Klebsiella oxytoca, Serratia marcescens, Escherichia coli, and Citrobacter freundii) | |
| TMB-1 | B1 | Achromobacter spp., Acinetobacter spp., Enterobacterales (Enterobacter hormaechei and Citrobacter freundii) |
MBLs are shown according to their bacterial host range: in the first block, those confined to one or a few bacterial hosts are indicated, and in the second block, the enzymes widely distributed among different bacteria are indicated.
a
Bacterial strains frequently producing each MBL are shown and ordered by decreasing frequency in cases where the MBL is not confined to a single bacterium host.