Table 1.
Risk evaluation of hypouricaemia and mild hypouricaemia among 4993 Japanese participants
| Population | Factora | Odds ratio | 95% CI | P-value |
|---|---|---|---|---|
|
Hypouricaemia and mild hypouricaemia (SUA ≤3.0 mg/dl) |
Sexb | 9.52 | 5.74, 15.8 | 2.53 × 10–18 |
| Age | 0.968 | 0.946, 0.990 | 3.95 × 10–3 | |
| BMI | 0.832 | 0.772, 0.898 | 1.91 × 10–6 | |
| R90Hc | 22.7 | 6.34, 81.3 | 1.61 × 10–6 | |
| W258Xc | 29.4 | 18.1, 47.7 | 9.01 × 10–43 | |
|
| ||||
|
Hypouricaemia (SUA ≤2.0 mg/dl) |
R90Hc | 550.5 | 25.4, 11 930.5 | 5.79 × 10–5 |
| W258Xc | 302.8 | 38.2, 2401.6 | 6.40 × 10–8 | |
a
A logistic regression analysis using the backward elimination (likelihood ratio) method was conducted using models for sex, age, BMI and non-functional URAT1 variants (R90H and W258X). None of these covariates were eliminated in the risk evaluation of hypouricaemia and mild hypouricaemia (SUA ≤3.0 mg/dl), whereas sex, age and BMI were eliminated for hypouricaemia (SUA ≤2.0 mg/dl).
b
Calculation for sex was conducted for males as 1 and females as 2.
c
Calculations for the risk alleles of R90H and W258X were conducted for wild-type as 0, heterozygotes as 1 and homozygotes as 2.