Figure 2.

VRC07-523LS binding to and elimination of LRV-infected cells. A, The frequency of infected cells with antibody bound to their surface (% p24+Ab+) and (B) MFI. CH65 antibody (Supplementary Reference 1) was used as negative control. C and D, End point concentrations (μg/mL), the concentration at which at least 15% target cell killing occurs. The data represent a single experiment with mAb starting with 100 µg/mL and subsequent 1:5 dilutions tested in duplicate. Statistical significance was calculated using Wilcoxon signed rank test. Horizontal lines indicate mean. Abbreviations: EC, end point concentration; LRV, latent reservoir virus; mAb, monoclonal antibody; MFI, mean fluorescence intensity; NS, not significant.