Table 4.

Uni- and Multivariate Cox Regression Analysis for the Overall Risk of Therapy Requirements (therapy escalation or need for steroids) and Disease Complications (Hospitalization, Disease Extension, or Colectomy)

	Therapy Requirements				Disease complications
	Univariate	P	Multivariate	P	Univariate	P	Multivariate	P
Age at diagnosis	0.99 (0.96-1.0)	P = 0.33	0.98 (0.96-1.0)	P = 0.25	0.98 (0.95-1.0)	P = 0.11	0.97 (0.95-1.0)	P = 0.07
Endoscopic inflammation at diagnosis (Mayo score < 2 vs ≥ 2)	1.8 (0.69-4.7)	P = 0.23	1.98 (0.71-5.5)	P = 0.19	0.98 (0.41-2.4)	P = 0.96	1.01 (0.39-2.6)	P = 0.98
Disease extent at diagnosis (Montreal classification E1 vs E2)	1.5 (0.62-3.5)	P = 0.38	1.2 (0.46-3.1)	P = 0.71	1.1 (0.45-2.6)	P = 0.84	1.11 (0.40-3.1)	P = 0.83
Nancy score (< 3 vs ≥ 3)	2.0 (0.58-6.8)	P = 0.27	2.09 (0.56-7.8)	P = 0.27	1.5 (0.5-4.5)	P = 0.47	1.86 (0.57-5.6)	P = 0.31
Histologic involvement above the endoscopic margin (yes vs no)	2.8 (0.82-9.4)	P = 0.10	3.69 (1.05-13)	P = 0.04	4.2 (0.99-18)	P = 0.052	4.79 (1.1-20.9)	P = 0.04