Table 2.
Synovial fibroblast heterogeneity [19]
| Markers defining this population | Name in Zhang et al. 2019 | Associated with RA/OA | Possible function, associated expression profile | Position in the synovium | Mouse equivalent (Croft et al. 2019) |
|---|---|---|---|---|---|
| CD34+ | SC-F1 | Associated with inflammation in RA | Expression of IL6, CXCL12, CCL2; potential role in monocyte recruitment (Mizoguchi et al. 2018) | Sublining: observed in both superficial and deeper sublining areas (Mizoguchi et al. 2018) | |
| HLA-DRAhi | SC-F2 | Associated with inflammation in RA | MHC II antigen presentation and IFNγ signalling; production of proinflammatory cytokines; potential role in leukocyte infiltration (Mizoguchi et al. 2018) | Sublining | FAPα+THY1+CD34- (STIA Col11a1+ F1 population) |
| DKK3 | SC-F3 | No association found | Identified as a novel subpopulation with high expression of DKK3, CAMD1, COL8A2 | Sublining | |
| CD55 | SC-F4 | OA associated | murine FAPα+THY- lining fibroblast may be potentially associated with bone and cartilage erosion (Croft et al. 2019) | Lining | Similarity to FAPα+THY- lining fibroblasts, (STIA F5 lining population) |