Table 1.
Association Between Transforming Growth Factor β1 Single-Nucleotide Polymorphisms and Tuberculosis Susceptibility in the Discovery Cohort
| No. (%) | Multiplicative Model | Additive Model | Dominant Model | Recessive Model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP ID and Genotype | Control Group | Tuberculosis Group | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) |
| rs2317130 (5-near) | ||||||||||
| CC | 424 (29.4) | 515 (33.6) | .01 | 1.14 (1.03–1.26) | .01 | 1.29 (1.05–1.60) | .12 | 1.16 (.96–1.40) | .01 | 1.21 (1.04–1.42) |
| CT | 742 (51.3) | 756 (49.3) | .42 | 1.09 (.89–1.32) | ||||||
| TT | 279 (19.3) | 262 (17.1) | Reference | Reference | ||||||
| rs4803457(5-near) | ||||||||||
| TT | 405 (28.0) | 494 (32.2) | .01 | 1.14 (1.03–1.26) | .01 | 1.29 (1.05–1.59) | .13 | 1.15 (.96–1.38) | .01 | 1.22 (1.04–1.43) |
| CT | 747 (51.7) | 762 (49.7) | .44 | 1.08 (.89–1.31) | ||||||
| CC | 293 (20.3) | 277 (18.1) | Reference | Reference | ||||||
| rs11466313(5-near) | ||||||||||
| DEL.DEL | 427 (29.3) | 522 (34.0) | .002 | 1.17 (1.06–1.30) | .003 | 1.36 (1.11–1.68) | .02 | 1.23 (1.03–1.48) | .008 | 1.23 (1.05–1.44) |
| DEL.AGG | 712 (49.0) | 737 (48.1) | .14 | 1.16 (.95–1.40) | ||||||
| AGG.AGG | 306 (21.7) | 274 (17.9) | Reference | Reference | ||||||
| rs17516265(5-near) | ||||||||||
| AA | 1391 (96.3) | 1470 (95.9) | .55 | 1.12 (.78–1.61) | … | … | … | … | … | … |
| AC | 54 (3.3) | 62 (4.0) | … | … | ||||||
| CC | 0 (0) | 1 (.1) | … | … | ||||||
| rs8110090 (intron) | ||||||||||
| AA | 1427 (98.8) | 1515 (98.8) | .86 | 1.06 (.55–2.04) | … | … | … | … | … | … |
| AG | 18 (1.2) | 18(1.2) | … | … | ||||||
| GG | 0 (0) | 0 (0) | … | … | ||||||
| rs4803455 (intron) | ||||||||||
| CC | 532 (36.8) | 666 (43.4) | .001 | 1.20 (1.08–1.33) | .01 | 1.35 (1.07–1.70) | .17 | 1.16 (.94–1.44) | <.001 | 1.31 (1.14–1.53) |
| CA | 714 (49.4) | 682 (44.5) | .81 | 1.03 (.82–1.29) | ||||||
| AA | 199 (13.8) | 185 (12.1) | Reference | Reference | ||||||
| rs3087453 (5-near) | ||||||||||
| CC | 1444 (99.9) | 1532 (99.9) | .97 | 1.06 (.07–16.98) | … | … | … | … | … | … |
| CG | 1 (.1) | 1 (.1) | … | … | ||||||
| GG | 0 | 0 | … | … | ||||||
| rs2278422 (intron) | ||||||||||
| CC | 1376 (95.2) | 1452 (94.7) | .54 | 1.11 (.80–1.52) | .96 | 1.06 (.15–7.51) | .95 | 1.06 (.15–7.55) | .53 | 1.11 (.80–1.55) |
| CG | 67 (4.7) | 79 (5.2) | .87 | 1.18 (.16–8.60) | ||||||
| GG | 2 (.1) | 2 (.1) | Reference | Reference | ||||||
| rs1800469 (5-near) | ||||||||||
| CC | 403 (27.9) | 433 (28.2) | .90 | 1.01 (.91–1.11) | .91 | 1.01 (.83–1.24) | .98 | 1.00 (.85–1.19) | .83 | 1.02 (.87–1.19) |
| CA | 705 (48.8) | 742 (48.4) | .92 | 1.01 (.84–1.21) | ||||||
| AA | 337 (23.3) | 358 (23.4) | Reference | Reference | ||||||
| rs11466334 (intron) | ||||||||||
| CC | 1262 (87.3) | 1427 (93.1) | <.001 | 1.91 (1.50–2.43) | .11 | 2.54 (.79–8.28) | .13 | 2.40 (.74–7.80) | <.001 | 1.95 (1.52–2.51) |
| TC | 174 (12.0) | 102 (6.7) | .65 | 1.32 (.40–4.39) | ||||||
| TT | 9 (.7) | 4 (.2) | Reference | Reference | ||||||
Abbreviations: CI, confidence interval; ID, identifier; OR, odds ratio; SNP, single-nucleotide polymorphism.