Table 2.
Association between selected SNPs and RA with PF (n = 60) and population controls (n = 1292) and in RA patients with and without PF (in simple logistic regression analyses adjusted for sex, smoking habits and age at DNA sampling or age at RA onset, respectively) analysed for each SNP separately
| rs Identifier | Risk allele | RA-PF vs controls |
RA-PF vs RA without PF |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF (RA/C) | OR (95% CI) | Crude P-value | OR (95% CI) | Adjusted P-value | q-Value | MAF | OR (95% CI) | Crude P-value (ILD/no ILD) | OR (95% CI) | Adjusted P-value | q-Value | ||
| rs35705950 | T | 0.26/0.12 | 2.39 (1.48, 3.76) | 0.00021 | 4.41 (1.88, 10.66) | 0.00069 | 0.009 | 0.26/0.11 | 2.57 (1.58, 4.10) | 8.9e-05 | 2.52 (1.54, 4.04) | 0.00016 | 0.0021 |
| rs111521887 | G | 0.33/0.19 | 2.09 (1.40, 3.08) | 0.00025 | 2.35 (1.25, 4.48) | 0.0083 | 0.054 | 0.33/0.20 | 1.91 (1.28, 2.80) | 0.0011 | 1.89 (1.27, 2.78) | 0.0014 | 0.0092 |
| rs2609255 | G | 0.33/0.24 | 1.58 (1.07, 2.30) | 0.018 | 1.34 (0.72, 2.49) | 0.35 | 0.65 | 0.33/0.23 | 1.69 (1.13, 2.50) | 0.0096 | 1.67 (1.11, 2.49) | 0.013 | 0.055 |
| rs7887 | T | 0.47/0.37 | 1.55 (1.07, 2.23) | 0.019 | 1.54 (0.85, 2.79) | 0.15 | 0.43 | 0.47/0.42 | 1.23 (0.85, 1.79) | 0.27 | 1.21 (0.83, 1.77) | 0.32 | 0.59 |
| rs2736100 | A | 0.61/0.55 | 1.25 (0.86, 1.83) | 0.24 | 1.60 (0.91, 2.93) | 0.11 | 0.43 | 0.61/0.53 | 1.39 (0.96, 2.03) | 0.085 | 1.47 (1.01, 2.15) | 0.046 | 0.15 |
| rs12610495 | G | 0.43/0.38 | 1.23 (0.84, 1.77) | 0.28 | 0.98 (0.51, 1.83) | 0.94 | 0.94 | 0.43/0.36 | 1.35 (0.92, 1.96) | 0.12 | 1.31 (0.89, 1.92) | 0.16 | 0.42 |
| rs2076295 | G | 0.47/0.41 | 1.29 (0.91, 1.85) | 0.15 | 1.14 (0.64, 2.06) | 0.65 | 0.84 | 0.47/0.42 | 1.25 (0.86, 1.82) | 0.25 | 1.25 (0.86, 1.83) | 0.24 | 0.53 |
| rs5743890 | C | 0.08/0.10 | 0.85 (0.41, 1.56) | 0.62 | 0.95 (0.34, 2.45) | 0.92 | 0.94 | 0.08/0.11 | 0.75 (0.36, 1.39) | 0.40 | 0.75 (0.36, 1.40) | 0.41 | 0.66 |
| rs4727443 | C | 0.38/0.36 | 1.10 (0.76, 1.59) | 0.61 | 0.68 (0.36, 1.35) | 0.23 | 0.50 | 0.38/0.36 | 1.08 (0.74, 1.58) | 0.68 | 1.07 (0.73, 1.56) | 0.73 | 0.93 |
| rs1278769 | G | 0.22/0.21 | 1.04 (0.66, 1.60) | 0.86 | 1.21 (0.60, 2.37) | 0.59 | 0.84 | 0.22/0.24 | 0.89 (0.57, 1.46) | 0.61 | 0.93 (0.58, 1.42) | 0.73 | 0.93 |
| rs11191865 | A | 0.44/0.47 | 0.90 (0.63, 1.29) | 0.58 | 0.66 (0.36, 1.18) | 0.17 | 0.43 | 0.44/0.46 | 0.91 (0.63, 1.32) | 0.62 | 0.95 (0.65, 1.38) | 0.79 | 0.93 |
| rs6793295 | C | 0.32/0.29 | 1.12 (0.75, 1.65) | 0.56 | 1.04 (0.55, 1.93) | 0.89 | 0.94 | 0.32/031 | 1.01 (0.68, 1.49) | 0.95 | 1.04 (0.69, 1.53) | 0.86 | 0.93 |
| rs2034650 | A | 0.50/0.46 | 1.20 (0.83, 1.73) | 0.34 | 1.17 (0.65, 2.11) | 0.60 | 0.84 | 0.50/0.49 | 1.02 (0.70, 1.49) | 0.90 | 1.01 (0.69, 1.47) | 0.98 | 0.98 |