Table 3.
Association between RA with and without PF analysed in simple logistic regression analyses for each SNP with adjustments
| rs Identifier | Risk allele | RA with vs. without PF with adjustmentsa |
RA with vs. without PF with adjustmentsb |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF (ILD+/ILD−) | OR (95% CI) | Crude P-value | OR (95% CI) | Adjusted P-value | q-Value | MAF (ILD+/ILD−) | OR (95% CI) | Crude P-value | OR (95% CI) | Adjusted P-value | q-Value | ||
| rs35705950 | T | 0.27/0.11 | 2.81 (1.71, 4.53) | 2.8e-05 | 2.65 (1.59, 4.32) | 0.00012 | 0.0015 | 0.26/0.11 | 2.74 (1.65, 4.43) | 5.5e-05 | 2.56 (1.54, 4.21) | 0.00023 | 0.0029 |
| rs111521887 | G | 0.34/0.20 | 1.95 (1.30, 2.89) | 0.00093 | 1.90 (1.27, 2.81) | 0.0016 | 0.010 | 0.34/0.20 | 2.01 (1.34, 2.98) | 0.00060 | 1.96 (1.31, 2.92) | 0.00098 | 0.0063 |
| rs2609255 | G | 0.33/0.23 | 1.63 (1.08, 2.43) | 0.017 | 1.63 (1.07, 2.45) | 0.021 | 0.090 | 0.32/0.23 | 1.59 (1.05, 2.38) | 0.026 | 1.61 (1.05, 2.44) | 0.027 | 0.12 |
| rs2736100 | Ac | 0.60/0.53 | 1.36 (0.94, 2.00) | 0.11 | 1.42 (0.97, 2.09) | 0.076 | 0.25 | 0.60/0.53 | 1.33 (0.91, 1.95) | 0.14 | 1.38 (0.94, 2.05) | 0.10 | 0.33 |
| rs2076295 | G | 0.47/0.42 | 1.25 (0.85, 1.84) | 0.25 | 1.29 (0.88, 1.91) | 0.19 | 0.45 | 0.46/0.42 | 1.21 (0.82, 1.77) | 0.34 | 1.25 (0.84, 1.85) | 0.26 | 0.59 |
| rs12610495 | G | 0.43/0.36 | 1.33 (0.91, 1.95) | 0.14 | 1.28 (0.87, 1.88) | 0.21 | 0.45 | 0.42/0.36 | 1.28 (0.87, 1.88) | 0.21 | 1.22 (0.83, 1.80) | 0.31 | 0.59 |
| rs7887 | T | 0.48/0.42 | 1.27 (0.87, 1.86) | 0.21 | 1.18 (0.79, 1.77) | 0.42 | 0.75 | 0.48/0.42 | 1.27 (0.87, 1.86) | 0.22 | 1.18 (0.78, 1.77) | 0.44 | 0.71 |
| rs5743890 | C | 0.09/0.11 | 0.77 (0.37, 1.43) | 0.45 | 0.78 (0.37, 1.45) | 0.46 | 0.75 | 0.08/0.11 | 0.70 (0.33, 1.33) | 0.32 | 0.70 (0.32, 1.34) | 0.32 | 0.59 |
| rs6793295 | C | 0.33/0.31 | 1.06 (0.71, 1.57) | 0.76 | 1.11 (0.73, 1.65) | 0.61 | 0.89 | 0.33/0.32 | 1.09 (0.72, 1.61) | 0.69 | 1.13 (0.75, 1.68) | 0.56 | 0.82 |
| rs11191865 | A | 0.44/0.46 | 0.90 (0.62, 1.32) | 0.60 | 0.93 (0.63, 1.37) | 0.73 | 0.95 | 0.44/0.46 | 0.90 (0.61, 1.32) | 0.60 | 0.93 (0.63, 1.38) | 0.73 | 0.87 |
| rs1278769 | G | 0.22/0.24 | 0.93 (0.59, 1.42) | 0.75 | 0.94 (0.59, 1.46) | 0.80 | 0.95 | 0.22/0.24 | 0.90 (0.56, 1.39) | 0.65 | 0.90 (0.56, 1.40) | 0.67 | 0.87 |
| rs2034650 | A | 0.49/0.50 | 0.98 (0.67, 1.44) | 0.93 | 0.99 (0.67, 1.46) | 0.96 | 0.97 | 0.48/0.50 | 0.95 (0.64, 1.39) | 0.77 | 0.96 (0.65, 1.42) | 0.84 | 0.91 |
| rs4727443 | C | 0.36/0.36 | 0.99 (0.67, 1.46) | 0.98 | 1.01 (0.67, 1.49) | 0.97 | 0.97 | 0.36/0.36 | 0.98 (0.66, 1.45) | 0.92 | 1.0 (0.67, 1.48) | 1.0 | 1.0 |
Only patients with no missing values are included.
a
Adjusted for sex, age at RA diagnosis, smoking habits, anti-CCP, RF and HLA-shared epitope.
b
Adjusted for sex, age at diagnosis, smoking habits, anti-CCP, RF, HLA-shared epitope and DAS28 at the index date.
c
PF-associated allele.
MAF: minor allele frequency.