Table 5.

Logistic regression analyses with PF as the outcome with the top three SNPs included (rs2609255, rs111521887 and rs35705950) and covariates included as adjustments in previous analyses in multivariable regression models and registered at the index date

Variables	rs 2609255		rs111521887		rs35705950
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
SNP	2.04 (1.22, 3.39)	0.0057	2.19 (1.34, 3.55)	0.0015	2.67 (1.38, 5.02)	0.0026
Sex, female/male	0.80 (0.39, 1.69)	0.54	0.80 (0.39, 1.69)	0.55	0.49 (0.22, 1.09)	0.075
Age at RA diagnosis	1.05 (1.02, 1.08)	0.0030	1.05 (1.02, 1.09)	0.0017	1.05 (1.01, 1.09)	0.0097
Ever-smoker, +/−	2.31 (1.02, 5.92)	0.058	2.30 (1.02, 5.89)	0.060	3.21 (1.17, 11.41)	0.040
BMI, kg2/ma	1.03 (0.95, 1.11)	0.45	1.04 (0.96, 1.12)	0.32	1.05 (0.95, 1.15)	0.29
DAS28	0.90 (0.71, 1.16)	0.42	0.93 (0.73, 1.19)	0.54	0.84 (0.64, 1.11)	0.23
MTX	0.39 (0.19, 0.87)	0.016	0.38 (0.18, 0.84)	0.013	0.46 (0.18, 1.27)	0.11
ACPA +/−	1.16 (0.48, 3.09)	0.76	1.30 (0.53, 3.54)	0.59	1.57 (0.51, 6.03)	0.47
RF +/−	2.78 (0.94, 10.36)	0.088	2.62 (0.88, 9.84)	0.11	4.05 (1.03, 27.30)	0.080
HLA-shared epitopeb	0.95 (0.44, 2.22)	0.91	0.81 (0.38, 1.87)	0.61	0.90 (0.36, 2.45)	0.82

^aMissing values for BMI are imputed.

^bHLA-shared epitope includes 0401/0404/0405/0408/0101.