Table 3.

Mixed model for repeated measures analyses for anxiety, depression and quality of life scores

	STAI state-anxiety score			EPDS score			Summary physical health score*			Summary mental health score*
Fixed effect	P value†			P value†			P value†			P value†
Questionnaire set no	<0.0001			0.0001			0.3			<0.0001
Gestation at first visit‡	0.7			0.4			0.2			0.2
Prior mental health condition‡	0.7			0.09			0.6			0.006
Obstetric history ‡ ¶	0.4			0.04			0.8			0.3
Least squares means	Estimate	95% CI		Estimate	95% CI		Estimate	95% CI		Estimate	95% CI
Set 1	39.0	35.6 to 42.4		7.5	6.1 to 8.9		70.9	63.9 to 77.8		60.7	55.8 to 65.6
Set 2	36.5	33.0 to 40.0		6.3	4.9 to 7.7		67.2	60.1 to 74.4		62.5	57.5 to 67.4
Set 3	32.6	29.1 to 36.1		5.7	4.3 to 7.1		71.5	64.3 to 78.6		69.5	64.6 to 74.5
Least squares means difference	Estimate	95% CI	P value§	Estimate	95% CI	P value§	Estimate	95% CI	P value§	Estimate	95% CI	P value§
Set 2–1	−2.5	−5.5 to 0.5	0.1	−1.2	−2.3 to 0.2	0.02	−3.7	−10.1 to 2.8	0.3	1.8	−3.1 to 6.6	0.5
Set 3–1	−6.4	−8.8 to 4.0	<0.0001	−1.8	−2.6 to 1.0	<0.0001	0.6	−4.6 to 5.8	0.8	8.9	4.7 to 13.0	<0.0001
Set 3–2	−3.9	−6.4 to 1.5	0.002	−0.6	−1.4 to 0.2	0.2	4.2	−1.1–9.6	0.1	7.1	−3.0 to −11.2	0.001

*RAND 36-Item Short Form Survey. Higher scores associated with better quality of life.

†Pr >F. Type 3 tests of fixed effects.

‡Analysis adjusted for these factors.

§Pr > |t|.

¶Categorised by no previous pregnancy beyond 12 weeks; loss/preterm birth at 12–28 weeks; loss/preterm birth at 28–37 weeks; or term birth only.

STAI, State Trait Anxiety Inventory; EPDS, Edinburgh Postnatal Depression Scale.;