Table 1.
Summary of oligodendrocyte differentiation
| Species | Cell sources | Regional identity | Target cell type (Efficiency) | Duration (Days) | Self-renewal | In vitro disease modeling | In vivo transplantation | References |
|---|---|---|---|---|---|---|---|---|
| Human | hESCs | Spinal Cord | PDGFRα＋ OPCs (>80%) | >90 days |
Not shown | Not shown | Newborn shiverer mice | Hu et al., 2009 |
| MBP＋ OLs (Not shown) | >120 days | |||||||
| Mouse | EpiSCs | Spinal Cord | PDGFRα＋ OPCs (∼90%) | >10 days | >passage 8 | Not shown | Newborn shiverer mice | Najm et al., 2011 |
| MBP＋ OLs (Not shown) | >13 days | |||||||
| Human | hESCs hiPSCs |
Spinal Cord | PDGFRα＋ OPCs (>30%) | >120 days |
Not shown | Not shown (Schizophrenia, as shown in Windrem et al., 2017; Huntington’s Disease, as shown in Osipovitch et al., 2019) | Newborn shiverer mice | Wang et al., 2013 |
| MBP＋ OLs (Not shown) | ∼200 days | |||||||
| Human | hESCs | Forebrain Spinal Cord |
NG2＋ OPCs (∼87%) | >120 days |
Not shown | Not shown (As shown in Djelloul et al., 2015) | Not shown | Stacpoole et al., 2013 |
| MBP＋ OLs (∼5%) | >135 days | |||||||
| Human | hESCs hiPSCs |
Spinal Cord | O4＋ OPCs (∼70%) | >50 days | Not shown | Not shown (Pelizaeus-Merzbacher Disease, as shown in Nevin., 2017; Schizophrenias, as shown in McPhie et al., 2018; Alexander disease, as shown in Li et al., 2018) | Newborn shiverer mice | Douvaras et al., 2014 and 2015 |
| MBP＋ OLs (∼20%) | ∼75 days | |||||||
| Human | hESCs hiPSCs |
Forebrain | PDGFRα＋ OPCs (25%) | >50 days |
Not shown | Not shown | Irradiated rats | Piao et al., 2015 |
| MBP＋ OLs (Not shown) | >85 days | |||||||
| Monkey Human |
mESCs hiPSCs |
Spinal Cord | PDGFRα＋ OPCs (>10%) | >57 days |
Not shown | Not shown | Newborn C57BL6/J mice | Yamashita et al., 2017 |
| MBP＋ OLs (∼4%) | >73 days | |||||||
| Human | hESCs | Not shown | PDGFRα＋ OPCs (>90%) | >28 days | Not shown | Not shown | Adult rat spinal cord | Kim et al., 2017 |
| Human | hESCs hiPSCs |
Hindbrain | PDGFRα＋ OPCs (>20%) | >65 days | Not shown | Not shown | Adult shiverer mice | Yun et al., 2019 |
| MBP＋ OLs (>3%) |
∼120 days |