Table 2.
Summary of Schwann cell differentiation
| Species | Cell sources |
Target cell type (Efficiency) |
Duration (Days) |
In vitro disease modeling | In vivo transplantation | References |
|---|---|---|---|---|---|---|
| Human | hESCs hiPSCs |
p75＋ NCSCs (∼30%) | >28 days |
Not shown | Chick embryos and adult NOD/SCID mice | Lee et al., 2007 Lee et al., 2010 |
| GFAP＋ or S100β＋ SCs (>5%) | >109 days | |||||
| Human | hESCs | GFAP＋ or S100β＋ SCs (∼60%) | ∼84 days | Not shown | Not shown | Ziegler et al., 2011 |
| Human | hESCs hiPSCs |
p75＋ NCSCs (Not shown) | >22 days |
Not shown | Adult rat sciatic nerve | Wang et al., 2011 |
| GFAP＋ or S100β＋ SCs (Not shown) | >34 days | |||||
| Human | hESCs hiPSCs |
p75＋ NCSCs (∼46%) | >14 days |
Not shown | In Ovo NCSC Injection | Liu et al., 2012 |
| GFAP＋ or S100β＋ SCs (Not shown) | >54 days | |||||
| Human | hESCs hiPSCs |
p75＋ NCSCs (∼80%) | >8 days |
Not shown | Not shown | Kreitzer et al., 2013 |
| GFAP＋ SCs (Not shown) | Not mentioned | |||||
| Human | hESCs hiPSCs |
SOX10＋ SCPs (∼99%) | >24 days |
Not shown | C57BL/6 mice sciatic nerve injury model | Kim et al., 2017 |
| S100β＋ or MPZ＋ SCs (Not shown) | >31 days | |||||
| Human | hiPSCs | p75＋ NCSCs (Not shown) | >20 days |
Not shown | Adult athymic nude rat sciatic nerve | Huang et al., 2017 |
| GFAP＋ or S100β＋ SCs (Not shown) | >41 days | |||||
| Human | hESCs hiPSCs PGD−hESCs |
CD49d＋ SCPs (∼18%) | >21 days | CMT1A pathogenesis | Mouse tibial nerve and rat models of chronic peripheral nerve denervation | Mukherjee-Clavin et al., 2019 |
| GFAP＋ or S100β+ SCs (Not shown) | ∼101 days |