TABLE A1.
Gompertz parameters for data generation in simulation study of IPCW regression model
|
Proportional subdistribution hazards, τ = 365 days
| |||||
| ρ | γ | Z 1 | Z 2 | RMTL, years | RMTL, days |
| −2.8 | 1.546588 | 1 | 1 | 0.30 | 109.5 |
| −2.9 | 2.291237 | 1 | 0 | 0.40 | 146.0 |
| −1.4 | 1.952647 | 0 | 1 | 0.45 | 164.25 |
| −1.7 | 2.879494 | 0 | 0 | 0.55 | 200.75 |
|
Nonproportional subdistribution hazards, τ = 365 days
| |||||
| ρ | γ | Z 1 | Z 2 | RMTL, years | RMTL, days |
| −1.7 | 1.213444 | 1 | 1 | 0.30 | 109.5 |
| −1.7 | 1.770851 | 1 | 0 | 0.40 | 146.0 |
| −1.7 | 2.096025 | 0 | 1 | 0.45 | 164.25 |
| −1.7 | 2.879494 | 0 | 0 | 0.55 | 200.75 |
Note: To assess the IPCW model, we generated competing risks data dependent on two binary covariates (Z1, Z2). We set the true conditional difference in RMTL at τ = 365 days, (β1, β2) = {μ1,1z2(τ) − μ1,0z2(τ), (μ1,z11(τ) − μ1,z10(τ)}.
Abbreviations: IPCW, inverse probability of censoring weighting; RMTL, restricted mean time lost.