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. 2022 Mar 2;189(3):128. doi: 10.1007/s00604-022-05242-4

Table 4.

Aptamer-based diagnostic strategies for COVID-19

Amplification strategies Target LOD Time (min) Portability Ref
RPA N gene 30 copies reaction−1 30 Portable [55]
Ligation-dependent isothermal reaction RNA-dependent RNA polymerase (RdRp) gene 1 aM 30 ~ 50 Nonportable [57]
CRISPR-Cas13 amplification N gene 80 copies reaction−1 20 Nonportable [58]
PLA N protein 0.0309 ng mL−1 120 Nonportable [59]
Thermoswimming signal amplification S protein 26,000 aM 15 Nonportable [60]
PIFE N protein 50 ng mL−1 2 Portable [62]