6. Results of the main analysis (simultaneous analysis of all tests against PCR‐based LOH), with results of the sensitivity analysis (separate analyses for each test with four or more studies) using PCR‐based LOH as the reference standard.
| Test | Number of studies | Main analysis | Sensitivity analysis | ||
| Sensitivity (95% CrI) | Specificity (95% CrI) | Sensitivity (95% CrI) | Specificity (95% CrI) | ||
| FISH | 15 | 0.91 (0.78 to 0.97) | 0.96 (0.90 to 0.99) | 0.91 (0.78 to 0.97) | 0.96 (0.90 to 0.99) |
| Real‐time PCR | 1 | 1.00 (0.77 to 1.00) | No data | Insufficient studies | |
| MLPA | 1 | 1.00 (0.74 to 1.00) | 1.00 (0.83 to 1.00) | Insufficient studies | |
| CGH | 6 | 0.94 (0.74 to 0.99) | 0.98 (0.91 to 1.00) | 0.93 (0.78 to 0.99) | 0.97 (0.91 to 1.00) |
| aCGH | 4 | 1.00 (0.97 to 1.00) | 0.96 (0.75 to 1.00) | 1.00 (0.97 to 1.00) | 0.95 (0.78 to 1.00) |
| SNP array | 2 | 0.97 (0.50 to 1.00) | 1.00 (0.92 to 1.00) | Insufficient studies | |
| NGS | 1 | 1.00 (0.86 to 1.00) | 0.98 (0.64 to 1.00) | Insufficient studies | |
| MS | 1 | 1.00 (0.85 to 1.00) | 1.00 (0.94 to 1.00) | Insufficient studies | |
| G‐banding | 1 | 0.00 (0.00 to 0.20) | 1.00 (0.78 to 1.00) | Insufficient studies | |
aCGH: array comparative genomic hybridisation; CGH: comparative genomic hybridisation; CrI: credible interval; FISH: fluorescence in situ hybridisation; LOH: loss of heterozygosity; MLPA: multiplex‐ligation‐dependent probe amplification; MS: mass spectrometry; NGS: next‐generation sequencing; PCR: polymerase chain reaction; SNP: single nucleotide polymorphism.