7. Differences in sensitivity (upper right triangle) and specificity (bottom left triangle) from analyses using PCR‐based LOH as the reference standard. Values are test in column minus test in row (95% credible interval). Positive values favour the test defining the column, negative values favour the test defining the row.
| Test | FISH | CGH | aCGH | SNP array | NGS | G‐banding | MLPA | Real‐time PCR | MS |
| FISH | — | 0.03 (−0.17 to 0.17) | 0.09 (0.03 to 0.22) | 0.05 (−0.41 to 0.19) | 0.09 (−0.05 to 0.21) | −0.9 (−0.97 to −0.68) | 0.08 (−0.17 to 0.21) | 0.08 (−0.14 to 0.21) | 0.09 (−0.06 to 0.21) |
| CGH | −0.02 (−0.08 to 0.05) | — | 0.05 (0 to 0.25) | 0.02 (−0.44 to 0.22) | 0.05 (−0.08 to 0.25) | −0.93 (−0.99 to −0.65) | 0.05 (−0.2 to 0.25) | 0.05 (−0.16 to 0.25) | 0.05 (−0.09 to 0.25) |
| aCGH | 0 (−0.07 to 0.2) | 0.02 (−0.06 to 0.22) | — | −0.03 (−0.5 to 0.01) | 0 (−0.14 to 0.03) | −1 (−1 to −0.79) | 0 (−0.26 to 0.03) | 0 (−0.23 to 0.03) | 0 (−0.15 to 0.03) |
| SNP array | −0.04 (−0.1 to 0.04) | −0.02 (−0.09 to 0.06) | −0.04 (−0.24 to 0.04) | — | 0.03 (−0.09 to 0.49) | −0.95 (−1 to −0.43) | 0.03 (−0.2 to 0.49) | 0.03 (−0.17 to 0.49) | 0.03 (−0.1 to 0.49) |
| NGS | −0.02 (−0.08 to 0.32) | 0 (−0.07 to 0.34) | −0.02 (−0.21 to 0.31) | 0.02 (−0.05 to 0.36) | — | −1 (−1 to −0.69) | 0 (−0.25 to 0.13) | 0 (−0.22 to 0.13) | 0 (−0.14 to 0.13) |
| G‐banding | −0.04 (−0.1 to 0.17) | −0.01 (−0.09 to 0.19) | −0.04 (−0.24 to 0.16) | 0 (−0.07 to 0.21) | −0.02 (−0.35 to 0.18) | — | 1 (0.6 to 1) | 1 (0.63 to 1) | 1 (0.69 to 1) |
| MLPA | −0.04 (−0.1 to 0.12) | −0.02 (−0.09 to 0.14) | −0.04 (−0.24 to 0.12) | 0 (−0.07 to 0.16) | −0.02 (−0.35 to 0.13) | 0 (−0.21 to 0.15) | — | 0 (−0.21 to 0.25) | 0 (−0.14 to 0.25) |
| Real‐time PCR | 0.45 (−0.08 to 0.98) | 0.47 (−0.06 to 1) | 0.43 (−0.17 to 0.99) | 0.49 (−0.03 to 1) | 0.42 (−0.22 to 1) | 0.47 (−0.09 to 1) | 0.48 (−0.06 to 1) | — | 0 (−0.14 to 0.22) |
| MS | −0.04 (−0.1 to 0.02) | −0.02 (−0.09 to 0.04) | −0.04 (−0.24 to 0.02) | 0 (−0.08 to 0.05) | −0.02 (−0.36 to 0.03) | 0 (−0.21 to 0.05) | 0 (−0.16 to 0.05) | −0.49 (−1 to 0.02) | — |
aCGH: array comparative genomic hybridisation; CGH: comparative genomic hybridisation; FISH: fluorescence in situ hybridisation; LOH: loss of heterozygosity; MLPA: multiplex‐ligation‐dependent probe amplification; MS: mass spectrometry; NGS: next‐generation sequencing; PCR: polymerase chain reaction; SNP: single nucleotide polymorphism.