8. Results from latent class analyses of FISH and PCR‐based LOH.

Analysis	Sensitivity of FISH (95% CrI)	Specificity of FISH (95% CrI)	Sensitivity of PCR‐based LOH (95% CrI)	Specificity of PCR‐based LOH (95% CrI)
Assuming conditional independence	0.95 (0.83 to 1.00)	0.97 (0.93 to 0.99)	0.97 (0.90 to 1.00)	0.98 (0.91 to 1.00)
Allowing for conditional dependencies	0.90 (0.74 to 0.99)	0.96 (0.91 to 0.99)	0.94 (0.80 to 0.99)	0.98 (0.89 to 1.00)
With an informative prior distribution forcing sensitivity of PCR‐based LOH to be ≥ 95%	0.92 (0.78 to 0.99)	0.96 (0.90 to 0.99)	0.97 (0.95 to 1.00)	0.98 (0.88 to 1.00)

These results are derived from 910 participants from 16 studies for whom test results were available for both FISH and PCR‐based LOH.

CrI: credible interval; FISH: fluorescence in situ hybridisation; LOH: loss of heterozygosity; PCR: polymerase chain reaction.