10. Costs and diagnostic accuracy of diagnostic tests to evaluate 1p/19q status codeletion (FISH as reference standard).
| Inputs | Deterministic analysis | Probabilistic sensitivity analysis | ||||||||
| Incremental cost per TP detected | ||||||||||
| Diagnostic test | Cost (GBP) | Effect (TP rate) | Incremental cost (GBP) | Incremental effect | ICER (GBP) | Prob of being CE at WTP of GBP 0 per TP | Prob of being CE at WTP of GBP 500 per TP | Prob of being CE at WTP of GBP 1000 per TP | Prob of being CE at WTP of GBP 5000 per TP | Prob of being CE at WTP of GBP 10,000 per TP |
| MLPA | 73 | 0.27 | — | — | — | 100% | 100% | 95% | 46% | 26% |
| PCR‐based LOH | 142 | 0.25 | — | — | Dominated | 0% | 0% | 0% | 0% | 0% |
| Real‐time PCR | 142 | 0.24 | — | — | Dominated | 0% | 0% | 2% | 2% | 1% |
| CISH | 186 | 0.30 | 113 | 0.03 | 3827 | 0% | 0% | 3% | 39% | 48% |
| aCGH | 233 | 0.29 | — | — | Dominated | 0% | 0% | 0% | 13% | 25% |
| SNP array | 257 | 0.23 | — | — | Dominated | 0% | 0% | 0% | 0% | 0% |
| NGS | 571 | 0.28 | — | — | Dominated | 0% | 0% | 0% | 0% | 0% |
| Incremental cost per TN detected | ||||||||||
| Diagnostic test | Cost (GBP) | Effect (TN rate) | Incremental cost (GBP) | Incremental effect | ICER (GBP) | Prob of being CE at WTP of GBP 0 per TN | Prob of being CE at WTP of GBP 500 per TN | Prob of being CE at WTP of GBP 1000 per TN | Prob of being CE at WTP of GBP 5000 per TN | Prob of being CE at WTP of GBP 10,000 per TN |
| MLPA | 73 | 0.45 | — | — | — | 100% | 16% | 1% | 0% | 0% |
| PCR‐based LOH | 142 | 0.65 | — | — | Dominated | 0% | 30% | 28% | 13% | 7% |
| Real‐time PCR | 142 | 0.66 | 69 | 0.22 | 326 | 0% | 54% | 71% | 73% | 67% |
| CISH | 186 | 0.59 | — | — | Dominated | 0% | 0% | 0% | 2% | 2% |
| aCGH | 233 | 0.66 | — | — | Dominated | 0% | 0% | 0% | 9% | 15% |
| SNP array | 257 | 0.66 | — | — | Dominated | 0% | 0% | 0% | 3% | 5% |
| NGS | 571 | 0.69 | 498 | 0.24 | 2111 | 0% | 0% | 0% | 0% | 4% |
| Incremental cost per CD | ||||||||||
| Diagnostic test | Cost (GBP) | Effect (CD rate) | Incremental cost (GBP) | Incremental effect | ICER (GBP) | Prob of being CE at WTP of GBP 0 per CD | Prob of being CE at WTP of GBP 500 per CD | Prob of being CE at WTP of GBP 1000 per CD | Prob of being CE at WTP of GBP 5000 per CD | Prob of being CE at WTP of GBP 10,000 per CD |
| MLPA | 73 | 0.72 | — | — | — | 100% | 23% | 4% | 0% | 0% |
| PCR‐based LOH | 142 | 0.90 | — | — | Dominated | 0% | 27% | 24% | 2% | 0% |
| Real‐time PCR | 142 | 0.91 | 69 | 0.19 | 362 | 0% | 47% | 54% | 27% | 18% |
| CISH | 186 | 0.89 | — | — | Dominated | 0% | 3% | 10% | 12% | 9% |
| aCGH | 233 | 0.95 | 160 | 0.24 | 673 | 0% | 0% | 8 | 58% | 60% |
| SNP array | 257 | 0.89 | — | — | Dominated | 0% | 0% | 0% | 0% | 0% |
| NGS | 571 | 0.97 | 498 | 0.25 | 1968 | 0% | 0% | 0% | 1% | 13% |
Tests ordered by cost. Diagnostic accuracy figures rounded to 3 decimal places. ICERs based upon exact values for incremental outcomes and costs. aCGH: array comparative genomic hybridisation; CD: correct diagnosis; CE: cost‐effective; CISH: chromogenic in situ hybridisation; FISH: fluorescence in situ hybridisation; ICER: incremental cost‐effectiveness ratio; LOH: loss of heterozygosity; NGS: next‐generation sequencing; PCR: polymerase chain reaction; SNP: single nucleotide polymorphism; TN: true negative; TP: true positive; WTP: willingness to pay.