Fig. 2.

Comparisons of anticorrelations (i.e., negative connectivity) with MPFC between HC and FEP 0 groups. (A) Anticorrelation maps with MPFC in HC and FEP 0 groups. (B) One cluster in DLPFC showed significantly reduced anticorrelation or increased connectivity in FEP 0 group compared to the HC group. (C) The FEP 0 group showed increased FCS in the DLPFC compared to the HC group (p = 0.015). Abbreviations: FCS, functional connectivity strength; HC, healthy control; FEP 0, first-episode psychosis patients at baseline; DMN, default mode network; DLPFC, dorsolateral prefrontal cortex. Two-tailed two-sample t-tests were used for the comparison. * p < 0.05.