Fig. 3.

The coupled changes of neurometabolites concentrations and FCS in the DMN. (A) The placement of the ¹H-MRS voxel (blue) along with the spectrum fitted by LCModel. (B) Comparisons of GABA, Glx, and NAA concentrations between HC and FEP 0 groups. (C) The changes of GABA level in the MPFC were negatively correlated with the alterations of FCS in the MPFC of the patients. (D) The changes of NAA level in the MPFC were negatively correlated with the alterations of FCS in the PCC/PCu of the patients. $\mathrm{\Delta }$ denotes the changes before and after treatment. Abbreviations: FCS, functional connectivity strength; DMN, default mode network; HC, healthy control; FEP 0, first-episode psychosis patients at baseline; FEP 1, first-episode psychosis patients at 8-week follow-up; MPFC, medial prefrontal cortex; PCC/PCu, posterior cingulate cortex/precuneus; GABA, gamma-aminobutyric acid; Glx, glutamate and glutamine; NAA, N-acetyl-aspartate. * p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)