Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 22;38(8):110415. doi: 10.1016/j.celrep.2022.110415

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Zinc modulation is an NMDAR-specific adaptation mechanism for overlapping synaptic patterns during multi-input integration

(A) L2/3 pyramidal cell morphology with two clusters of ten synapses each closely located on a dendritic branch.

(B) Example simulations of two-pattern integration in the presence (black) or absence (green dashed curve) of zinc-mediated inhibition of NMDAR and in the AMPA-only case (blue curve). From the two clusters of (A), we build two stimulation patterns by drawing spikes from a Gaussian distribution (5 ms width). We show the responses to the two individual patterns (left plots) and to the different combinations of the successive patterns separated by 50 ms in the non-overlapping (middle plots) and overlapping stimulation cases (right plots). In the insets, we show the same situation simulated with active properties (see STAR Methods).

(C) Reduction of the stimulus-evoked peak depolarization level due to the zinc inhibition for different number of synapses per pattern (y axis) and delays (x axis) between the two successive patterns. This was obtained by computing the absolute difference between peak depolarizations in the chelated-zinc and free-zinc (dashed green versus black curves, respectively) in (B) after averaging over n = 25 different dendritic branches.