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. 2022 Feb 16;11:806603. doi: 10.3389/fonc.2021.806603

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Copyright © 2022 Abousamra, Gupta, Hou, Batiste, Zhao, Shankar, Rao, Chen, Samaras, Kurc and Saltz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identifying Tumor Infiltrating Lymphocyte (TIL) regions in gigapixel pathology WSIs. (A) H&E stained WSI of lung adenocarcinoma. (B) Example of a region of tissue. (C) Example of a TIL map overlaid on the region of tissue. (D) Examples of TIL positive (framed in red) and negative (framed in green) patches. A lymphocyte is typically dark, round to ovoid, and relatively small compared to tumor and normal nuclei. Sample patches show the heterogeneity in TIL regions and how it can be challenging to differentiate TIL positive and TIL negative regions.