TABLE 7.
Quantitation of CMV glycoprotein H gene and detection of CMV transcripts in cells from BAL from immunocompromised patientsa
| Category | No. of BAL samples | Presence of IE-I mRNAb | Presence of gH mRNAb | gH copy no./μg of cell DNA
|
||
|---|---|---|---|---|---|---|
| Mean | Median | Range | ||||
| CMV seronegativeb | 8 | 0/8 | 0/8 | 0 | 0 | |
| CMV seropositive onlyc | 6 | 0/6 | 0/6 | 0 | 0 | |
| Asymptomatic CMV shedders | 18 | 7/18 | 0/18 | 72 | 20 | 0–352d |
| Definite CMV pneumonitis | 15 | 7/7 | 7/7 | 267,580 | 57,000 | 1,332–1,596,208 |
| Probable CMV pneumonitis | 4 | 4/4 | 4/4 | 16,128 | 11,992 | 1,002–40,095 |
a
Reprinted from reference 25 with permission of the publisher.
b
IE-I, immediate-early gene 1. Results are number of positive samples/total number.
c
BAL culture negative for CMV.
d
No viral DNA was detected in 6 of 18 samples.