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. Author manuscript; available in PMC: 2022 Aug 4.
Published in final edited form as: Science. 2022 Feb 3;375(6580):545–550. doi: 10.1126/science.abh4308

Fig. 1. Aliphatic C–H diversification using N-functionalized amides.

Fig. 1.

(A) A universal approach to C–H diversification would enable the introduction of a range of desired functionality onto small molecules and commodity polyolefins. (B) An N-functionalized amide and a diverse set of chain transfer agents constitute a general platform for C–H diversification. (C) The mechanistic hypothesis for C–H diversification using O-alkenylhydroxamates separates the HAT reagent from the chain transfer agent. Ar = 3,5-bis(trifluoromethyl)phenyl.