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. 2022 Feb 15;13:768606. doi: 10.3389/fimmu.2022.768606

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Copyright © 2022 Saito, Andrade, Bustos and Chammas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A simplified scheme of the phosphatidylcholine (PtdCho) cycle, highlighting the enzymes involved in PtdCho synthesis (Kennedy pathway) and catabolism (A). Representative structure of PtdCho consisted of a choline head group and a phosphate group (polar head group) linked to two fatty acid chains by a glycerol moiety (B). ChoK, choline kinase; CCT, CTP:phosphocholine cytidylyltransferase; CPT, CDP-choline cholinetransferase; LPCAT, lysophosphatidylcholine acyltransferase; PLA2, phospholipase A2; PC-PLC, phosphatidylcholine-specific phospholipase C; PC-PLD, phosphatidylcholine-specific phospholipase D; lyso-PLA, lysophospholipase; GPC-PDE, glycerophosphocholine phosphodiesterase. Created with BioRender.com.