Table 2.
Antibiotic susceptibility, therapeutic modalities, and outcomes
| Pt No | Susceptibility profile | First-line therapy | Final therapy | IFN-γ | Surgery | Outcome (Cause of death) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| RIF | INH | ETB | AMIK | CIP | ||||||
| 1 | R | S | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin | Isoniazid, Rifampin, Ethambutol, Ofloxacin, Dapsone, Cycloserine | Yes | Abdominal surgery, Lymphadenectomy | Deceased (Respiratory failure) |
| 2 | S | S | S | S | S | Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin (~ Pyrazinamide) | Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin | Yes | No | Alive |
| 3 | R | R | S | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin (~ Amikacin and Ethionamide) | Levofloxacin, Clarithromycin, Ethambutol, Cycloserine, Ethionamide, Linezolid, Clofazimine (~ Amikacin and Prothionamide) | Yes | Abdominal surgery | Alive |
| 4 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin, Amikacin | Yes | Lymphadenectomy | Alive |
| 5 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin | No | No | Alive |
| 6 | S | S | S | N/D | N/D | Rifampin, Ethambutol, Pyrazinamide, Clarithromycin | Isoniazid, Rifampin, Ethambutol, Levofloxacin | Yes | No | Alive |
| 7 | S | S | S | S | S | Ethambutol, Levofloxacin, Prothionamide, Cycloserine (~ Amikacin) | Isoniazid, Ethambutol, Levofloxacin | No | No | Alive |
| 8 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin, Ofloxacin (~ Dapsone, Clofazimine) | Ethambutol, Amikacin, Clarithromycin, Levofloxacin, Fluvoxamine, Prothionamide, Cycloserine | Yes | Abdominal surgery, lymphadenectomy | Alive |
| 9 | S | S | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin | Yes | Lymphadenectomy | Alive |
| 10 | R | R | S | S | R | Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin, Clarithromycin (~ Streptomycin, Prothionamide) | Amikacin, Levofloxacin, Cycloserine, Ethionamide, Clofazimine, Meropenem, Co-Amoxiclav | Yes | Abdominal surgery (Psoas abscess drainage) | Alive |
| 11 | R | S | S | S | S | Isoniazid, Rifampin, Ethambutol, Pyrazinamide | Isoniazid, Rifampin, Ethambutol, Levofloxacin, Co-Trimoxazole (~ Amikacin) | Yes | No | Alive |
| 12 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin (~ Cycloserine) | Isoniazid, Rifampin, Ethambutol, Clarithromycin | Yes | No | Alive |
| 13 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin | Isoniazid, Rifampin | No | Lymphadenectomy | Alive |
| 14 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin | No | No | Alive |
| 15 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin | Isoniazid, Rifampin, Ethambutol, Clarithromycin | Yes | No | Alive |
| 16 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin | Isoniazid, Rifampin, Ethambutol, Amikacin, Levofloxacin | No | Lymphadenectomy | Alive |
| 17 | S | S | S | S | S | Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin (~ Meropenem, Linezolid) | Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin, Cycloserine | Yes | Central vein catheterization | Alive |
| 18 | R | S | S | S | S | Isoniazid, Rifampin, Ethambutol | Rifampin, Levofloxacin, Cycloserine, Isoniazid, Ethambutol, Linezolid | No | Lymphadenectomy | Alive |
| 19 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin | Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin | Yes | No | Alive |
| 20 | R | S | R | S | S | Isoniazid, Ethambutol, Amikacin, Levofloxacin | Isoniazid, Ethambutol, Amikacin, Levofloxacin | Yes | Abdominal surgery, Lymphadenectomy | Alive |
| 21 | N/D | N/D | N/D | N/D | N/D | Isoniazid, Rifampin, Ethambutol | Rifampin, Isoniazid, Ethambutol | No | No | Alive |
| 22 | S | S | S | S | S | Isoniazid, Rifampin, Ethambutol, Ciprofloxacin | Rifampin, Isoniazid, Ethambutol, Levofloxacin, Amikacin | No | No | Alive |
| 23 | S | S | S | N/D | N/D | Isoniazid, Rifampin, Ethambutol, Levofloxacin | Isoniazid, Rifampin | No | Lymphadenectomy | Alive |
| 24 | S | S | S | N/D | N/D | Rifampin, Isoniazid, Levofloxacin, Amikacin | Rifampin, Isoniazid, Levofloxacin, Amikacin | No | Abdominal surgery, Lymphadenectomy | Deceased (Severe BCG infection) |
~ Used for a short time and discontinued
AMIK; amikacin, CIP; ciprofloxacin, ETB; ethambutol, N/D; not determined, INH; isoniazid, RIF; rifampin, S; sensible, R; resistant