Fig. 3.

NF1-aasociated pathways and genes in periodontitis or sicca syndrome identified by IPA. A Canonical pathway analysis was performed with RNA-seq data of dermal neurofibroma-derived Schwann cells from patients NF1 (n = 3, GSE14038), gingival tissues from patients with periodontitis (n = 3, GSE23586), as well as parotid glands from patients with sicca syndrome (n = 3, GSE66795). Top 20 NF1-associated canonical pathways for periodontal destruction and salivary gland dysfunction were listed. B IPA analyses showed putative network generated using published (solid lines) and predicted (dashed lines) between NF1 and periodontitis or sicca syndrome