Table 4.

Patients with CMN who died due to neurological complications

Total number of patients who died	34 (of a total of 2339 patients), excluding the studies that only reported neurological signs and symptoms in patients with MRI abnormalities: 24 (of a total of 2107 patients)
Age of neurological diagnosis	Mean: 5.86 years, median: 3 years, range: birth–27 years
Age of death	Mean: 7.44 years, median: 5.15 years, range: 0.7–28 years
Time between diagnosis and death	Mean: 1.43 years, median: 0.76 years, range: 0–4.4 years
Sex	Female: (n = 14), male: (n = 20)
Cause of death	Proliferating melanocytosis of the CNS (n = 19), malignant melanoma (n = 15)
Number of CMN	Multiple (n = 27), single (n = 0), unreported (n = 7)
Symptoms/signs	Neurodevelopmental delay (n = 9), seizures (n = 11), hydrocephalus/increased intracranial pressure (n = 28)