Fig. 7.

Serum 25-OHD levels (A–C), total IgG (D–F) and anti-NTHi IgG (G–I) in COPD patients treated with placebo or vitamin D for one year. Patients are subdivided according to their baseline levels of serum 25-OHD in severe deficiency (< 10 ng/ml serum 25OHD), deficiency (< 20 ng/ml) and insufficiency (< 30 ng/ml). Each point represents an individual patient. Serum levels of 25-OHD are expressed in ng/ml. Total IgG are expressed as mg/ml. Anti-NTHi IgG are expressed in arbitrary units (AU). ****p < 0.0001 (Mixed effect analysis with Bonferroni post-hoc test); ^$p < 0.05 (Paired T-test or Wilcoxon matched pairs)