Table 3.
Incidence rates and hazard ratios for primary and secondary outcomes in the outpatient cohort.
| Outcome | ACEI/ARB- vs. non-ACEI/ARB-exposed analysis |
ACEI vs. ARB-exposed analysis |
||
|---|---|---|---|---|
| ACEI/ARB-exposed | Non-ACEI/ARB-exposed | ACEI-exposed | ARB-exposed | |
| Primary outcome | ||||
| All-cause hospitalization or all-cause death | ||||
| No. of events | 671 | 344 | 373 | 274 |
| Person-time⁎ | 2349 | 1128 | 1140 | 1143 |
| Rate† | 28.6 | 30.5 | 32.7 | 24.0 |
| Crude HR (95% CI) | 0.92 (0.81, 1.05) | Ref. | 1.32 (1.13, 1.54) | Ref. |
| Adjusted HR (95% CI) | 1.01 (0.88, 1.15) | Ref. | 1.32 (1.13, 1.54) | Ref. |
| Secondary outcomes | ||||
| All-cause death | ||||
| No. of events | 106 | 62 | 54 | 48 |
| Person-time⁎ | 2511 | 1205 | 1230 | 1211 |
| Rate† | 4.2 | 5.1 | 4.4 | 4.0 |
| Crude HR (95% CI) | 0.80 (0.59, 1.10) | Ref. | 1.07 (0.72, 1.57) | Ref. |
| Adjusted HR (95% CI) | 0.78 (0.58, 1.07) | Ref. | 1.14 (0.78, 1.68) | Ref. |
| All-cause hospitalization | ||||
| No. of events | 565 | 282 | 319 | 226 |
| Person-time⁎ | 2407 | 1160 | 1169 | 1170 |
| Rate† | 23.5 | 24.3 | 27.3 | 19.4 |
| Crude HR (95% CI) | 0.95 (0.82, 1.10) | Ref. | 1.37 (1.16, 1.63) | Ref. |
| Adjusted HR (95% CI) | 1.07 (0.92, 1.24) | Ref. | 1.35 (1.14, 1.61) | Ref. |
⁎
Cumulative person-years (sum of all time-to-event across all patients).
†
No. of events divided by person-years, expressed per 100 person-years.