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. 2022 Mar 2;21:63. doi: 10.1186/s12943-022-01546-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Tissue-specific expression patterns of circRNAs in human normal tissues. A Heatmap of ubiquitously expressed circRNAs. B Heatmap of tissue-specifically expressed circRNAs. C The number of circRNAs produced from tissue-specific genes. D The Pearson correlation coefficients of tissue-specific circRNAs with host gene expression. E The tissue specificity of hsa_circ_0000497 was governed by the brain-specific host gene SLAIN1. F The Pearson correlation coefficients of tissue-specific circRNAs with RBP expression. G Expression of RBFOX1, hsa_circ_0070057 and its host gene SEPT11 in different tissues. H Correlation of hsa_circ_0070057 and RBFOX1 expression. I eCLIP-seq read density for RBFOX1 within introns flanking the hsa_circ_0070057 back-splicing site. The vertical red lines indicate the GCATG binding motifs of RBFOX1