Table 2.
Association between lipid profiles and gallstone disease with multivariate analysis by logistic regression
| First Affiliated Hospital of Chongqing Medical University Jinshan Hospital | The People’s Hospital of Kaizhou District of Chongqing | Tianjin Medical University Cancer Institute and Hospital | Pooled | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |
| TC, mmol/L | ||||||||
| < 3.1 | ref | ref | ref | |||||
| 3.1–5.7 | 0.714 (0.599, 0.852) | < 0.001 | 0.857 (0.688, 1.068) | 0.170 | ref | 0.767 (0.668, 0.880) | 1.51 × 10− 04 | |
| > 5.7 | 0.670 (0.557, 0.807) | < 0.001 | 0.765 (0.608, 0.964) | 0.023 | 0.855 (0.701, 1.043) | 0.122 | 0.754 (0.671, 0.848) | 2.25 × 10−06 |
| TG, mmol/L | ||||||||
| < 0.4 | ref | ref | ref | |||||
| 0.4–1.7 | 0.755 (0.524, 1.088) | 0.132 | 1.089 (0.476, 2.493) | 0.840 | ref | 0.801 (0.574, 1.119) | 0.194 | |
| > 1.7 | 0.897 (0.621, 1.296) | 0.562 | 1.272 (0.555, 2.916) | 0.570 | 0.982 (0.784, 1.230) | 0.874 | 0.972 (0.806, 1.172) | 0.764 |
| LDL-C, mmol/L | ||||||||
| < 2.07 | ref | ref | ref | |||||
| 2.07–3.1 | 0.932 (0.867, 1.002) | 0.055 | 0.902 (0.849, 0.958) | 0.001 | NA | 0.914 (0.873, 0.958) | 1.51 × 10−04 | |
| > 3.1 | 0.882 (0.815, 0.954) | 0.002 | 0.905 (0.831, 0.985) | 0.021 | NA | 0.893 (0.842, 0.946) | 1.31 × 10−04 | |
| HDL-C, mmol/L | ||||||||
| < 0.9 | ref | ref | ref | |||||
| 0.9–2.0 | 0.906 (0.824, 0.996) | 0.041 | 0.915 (0.822, 1.019) | 0.106 | NA | 0.910 (0.848, 0.977) | 0.009 | |
| > 2.0 | 0.698 (0.605, 0.804) | < 0.001 | 0.723 (0.623, 0.84) | < 0.001 | NA | 0.710 (0.640, 0.787) | 7.03 × 10−11 | |
| TC, per unit | 0.889 (0.827, 0.955) | 0.001 | 0.881 (0.829, 0.937) | < 0.001 | 0.939 (0.853, 1.033) | 0.197 | 0.895 (0.858, 0.933) | 1.89 × 10−07 |
| TG, per unit | 1.054 (1.033, 1.075) | < 0.001 | 1.05 (1.031, 1.07) | < 0.001 | 0.960 (0.862, 1.070) | 0.461 | 1.050 (1.036, 1.065) | 8.68 × 10−13 |
| LDLC, per unit | 1.071 (0.994, 1.153) | 0.071 | 1.071 (0.988, 1.161) | 0.094 | NA | 1.071 (1.014, 1.131) | 0.014 | |
| HDLC, per unit | 0.832 (0.750, 0.922) | < 0.001 | 0.930 (0.855, 1.012) | 0.091 | NA | 0.889 (0.833, 0.949) | 4.32 × 10−04 | |
The ORs were adjusted for age, sex, BMI, fatty liver disease, kidney stone, hypertension, FBG, Cr, UA, UN, T-bil, ALT, AST, and TC, TG, LDL-C, LDL-C. Bold means p < 0.05, TC: total cholesterol, TG triglycerides, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol